Main Title |
Armitage-Doll Two-Stage Model: Implications and Extension. |
Author |
Chen, C. W. ;
|
CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
Publisher |
c1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-93/293 ;OHEA-C-462; |
Stock Number |
PB93-222842 |
Additional Subjects |
Carcinogens ;
Risk assessment ;
Mathematical models ;
Hazards ;
Cancer ;
Exposure ;
Reprints ;
MVK model ;
Two-stage models ;
ADT model
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-222842 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The objective of the paper is twofold: (1) to provide insight on the simplified MVK model of carcinogenesis by revealing the relationship between the Armitage-Doll two-stage model (ADT model) and the simplified MVK model; and (2) to extend the ADT model to one with time-varying (piece-wise constant) parameters. It is shown that the simplified MVK model is a special case of the Armitage-Doll two-stage model , and many applications of the simplified MVK model involving intermittent exposures or exposures to different compounds in different time periods can be derived easily from the ADT model with piece-wise constant parameters. The limitations of the ADT model are discussed. (Copyright (c) 1993 Society for Risk Analysis.) |