Main Title |
Proliferative hepatocellular lesions of the rat : review and future use in risk assessment / |
Author |
Rinde, Esther ;
Hill, R. ;
Chiu, A. ;
Haberman, B.
|
Other Authors |
|
CORP Author |
Environmental Protection Agency, Washington, DC. Office of Pesticides and Toxic Substances. ;Environmental Protection Agency, Washington, DC. Office of Research and Development. |
Publisher |
U.S. Environmental Protection Agency, RiskAssessment Forum, |
Year Published |
1986 |
Report Number |
EPA/625/3-86/011 |
Stock Number |
PB87-178711 |
OCLC Number |
16016127 |
Subjects |
Carcinogenicity testing
|
Additional Subjects |
Risk ;
Liver neoplasms ;
Carcinogens ;
Malignant neoplasms ;
Liver diseases ;
Liver ;
Neoplasms ;
Rats
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJED |
EPA/625/3-86/011 |
|
OCSPP Chemical Library/Washington,DC |
01/26/2001 |
NTIS |
PB87-178711 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
vii, 22 p. : ill. ; 20 x 8 cm. |
Abstract |
The paper addresses three questions that are crucial in the evaluation of rat tumor data and in the assessment of carcinogenic risk for humans. One question is whether to consider these lesions 'hyperplastic' or 'neoplastic' in nature, the latter classification being indicative of tumor formation. A second question is to interpret the finding that in some experimental systems, certain nonmalignant proliferative lesions may regress following removal of an inciting, carcinogenic stimulus, with only a small proportion of the lesions persisting. Finally, it is important to know whether any of these lesions may progress to carcinoma. |
Notes |
"February 1986." "EPA/625/3-86/011."--Cover. "In memory of Dr. Bernard Haberman |