Record Display for the EPA National Library Catalog

RECORD NUMBER: 24 OF 61

OLS Field Name OLS Field Data
Main Title Micronuclei and Other Nuclear Anomalies in Buccal Smears: Methods Development.
Author Tolbert, P. E. ; Shy, C. M. ; Allen, J. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;North Carolina Univ. at Chapel Hill. School of Public Health.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/446;
Stock Number PB93-141455
Additional Subjects Mouth ; Carcinogenesis ; Tobacco ; Micronucleus tests ; Smokeless tobacco ; Chromosome aberrations ; Epidemiologic methods ; Genetic markers ; Epithelial cells ; Public health ; Radiation effects ; Reprints ; Buccal smears ; Snuff
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-141455 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/12/1993
Collation 11p
Abstract
Laboratory work aimed at improving the epidemiologic utility of an innovative genotoxicity marker is described. The exfoliated cell micronucleus assay involves microscope analysis of epithelial smears to determine the prevalence of micronucleation, an indicator of structural or numeric chromosomal aberrations. Exfoliated cells are moribund and undergo degenerative phenomena that can produce extranuclear objects difficult to distinguish from classical micronuclei. We also provide evidence that other nuclear anomalies are at least as common as micronucleation and that, therefore, there is the potential for extensive misclassification.