||Structure-Activity Relationships for Osteolathyrism. 1. Effects of Altering the Semicarbazide Structure.
Schultz, T. W. ;
Ranney, T. S. ;
Riggin, G. W. ;
Cajina-Quezada, M. ;
||Tennessee Univ., Knoxville.;Environmental Research Lab.-Duluth, MN.
Connective tissue ;
In vitro analysis ;
Xenopus laevis ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The toxic and osteolathyrogenic effects of 15 chemicals reflecting modifications of semicarbazide (H2N-N(H)-C(=O)-NH2) were evaluated using the Frog Embryo Teratogenesis Assay: Xenopus (FETAX). Osteolathyrism, the failure of connective tissue fibers to cross-link correctly, is expressed as gross alterations in the long axis of the embryo and a sinusoidal configuration of the notochord. Alteration (addition or subtraction) at the hydrazino (H2NNH-) end of the molecule sharply reduces osteolathyrogenic activity. Alteration at the amino (H2N-) end of the molecule results in a graded response. The replacement of oxygen with sulfur causes no loss of osteolathyrogenic activity. (Copyright (c) 1988 by the American Microscopical Society, Inc.)