Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Drinking Water Criteria Document for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.
CORP Author Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.
Publisher Apr 88
Year Published 1988
Report Number ECAO-CIN-405;
Stock Number PB90-215294
Additional Subjects Potable water ; Toxicology ; Water quality ; Mutagens ; Carcinogens ; Reproduction(Biology) ; Lethal dosage ; Exposure ; Laboratory animals ; Liver ; Metabolism ; Vitamin A group ; Tetrachlorodibenzodioxin ; Pharmacokinetics ; Water pollution effects(Humans) ; Water pollution effects(Animals) ; Health hazards ; Carcinogenicity tests ; Path of pollutants ; Mutagenicity tests ; Structure-activity relationship ; Lipid peroxidation
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB90-215294 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/03/1990
Collation 363p
2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is one of the most toxic and environmentally stable tricyclic aromatic compounds belonging to chlorinated dibenzo-p-dioxins. 2,3,7,8-TCDD has been demonstrated to be teratogenic in rats, mice and rabbits, and feticidal in monkeys. The major toxic signs and terata observed were cleft palate in mice, edema, hemorrhage, and kidney anomalies in rats and extra ribs in rabbits. Some epidemiological studies have indicated a possible teratogenic effect in humans, but the evidence is not sufficient to reach a firm conclusion.