Record Display for the EPA National Library Catalog


Main Title Thermoregulation in Laboratory Mammals and Humans Exposed to Anticholinesterase Agents.
Author Gordon, C. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher cSep 94
Year Published 1994
Report Number EPA/600/J-94/545;
Stock Number PB95-148078
Additional Subjects Cholinesterase inhibitors ; Body temperature regulation ; Toxicity ; Reprints ; Laboratory animals ; Humans ; Pesticides ; Cholinergic agents ; Drug antagonism ; Brown fat ; Exercise(Physiology) ; Physiologic adaptation ; Drug tolerance ; Variation(Genetics) ; Species specificity ;
Library Call Number Additional Info Location Last
NTIS  PB95-148078 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 29p
The regulation of body temperature is one of many homeostatic functions affected by exposure to anticholinesterase (antiChE) pesticides, and related compounds. In the study of antiChE neurotoxicity, thermoregulatory variables are often used as sensitive physiological indices. Hence, a review on the thermoregulatory aspects of antiChE agents would be useful to researchers in a variety of fields. In this review, the literature dealing with the central and peripheral effects of cholinergic agonists and antagonists is reassessed because the thermoregulatory effects of antiChEs are thought to be linked to the activation of cholinergic pathways. This is followed by a thorough review of the studies reporting thermoregulatory responses in laboratory rodents and humans exposed to low and high doses of a variety of antiChE agents, including the organophosphate- (OP) and carbamate- (CB) based pesticides and related drugs. Attention is given to the possible mechanism of action of OPs on thermoregulation in the laboratory rodent including the involvement of behavioral and autonomic processes. The incidence of antiChE-induced hyperthermia (fever) in humans exposed to antiChEs is also addressed. Other topics of antiChE-induced thermoregulatory dysfunction discussed in this review include the role of exercise, heat, and cold stress, tolerance to antiChE agents, and genetic variability.