Record Display for the EPA National Library Catalog


Main Title Biochemical Effects of Two Promoters of Hepatocarcinogenesis in Rats.
Author Kitchin, K. T. ; Brown, J. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div.
Year Published 1987
Report Number EPA/600/J-87/254;
Stock Number PB88-182365
Additional Subjects Liver neoplasms ; Phenobarbital ; Carcinogens ; Rats ; Pharmacology ; Deoxyribonucleic acids ; Toxicology ; Alpha amino carboxylic acids ; Valeric acid ; Cytochromes ; Biochemistry ; Reprints ; Butylated hydroxytoluene ; Ornithine decarboxylase
Library Call Number Additional Info Location Last
NTIS  PB88-182365 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
The effects of administration of two promoters of hepatocarcinogenesis on five hepatic biochemical parameters were examined in adult female rats. Two treatments of phenobarbital (100 mg/kg) 21 and 4 hours before sacrifice caused large increases in hepatic ODC activity and cytochrome P-450 content. Extending the number of phenobarbital treatments to 5 increased the size of hepatic enzyme induction and caused a minor decrease in hepatic glutathione and a small increase in serum alanine aminotransferase. Two administrations of butylated hydroxytoluene (BHT) (700 mg/kg) caused hepatic DNA damage and induction of both ODC activity and cytochrome P-450 content. Of the two compounds only BHT showed a potential for carcinogenic initiation. The biochemical parameters studied here, may form a useful biochemical system to examine a compound's potential to cause carcinogenic initiation, carcinogenic promotion and cellular toxicity.