Main Title |
Immune Alterations in Rats Following Subacute Exposure to Tributyltin Oxide. |
Author |
Smialowicz, R. J. ;
Riddle, M. M. ;
Rogers, R. R. ;
Luebke, R. W. ;
Copeland, C. B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;NSI Technology Services Corp., Research Triangle Park, NC. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/331; |
Stock Number |
PB91-149773 |
Additional Subjects |
Toxicology ;
Immune system ;
Pesticides ;
Rats ;
Dose-response relationships ;
Cyclophosphamide ;
Lipopolysaccharides ;
Erythrocytes ;
Plaque assay ;
T lymphocytes ;
Suppressor cells ;
Kinetics ;
Delayed hypersensitivity ;
Reprints ;
Tributyltin oxide
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-149773 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
Adult male Fischer 344 rats were dosed by oral gavage with bis(tri-n-butyltin) oxide (TBTO) in peanut oil on ten consecutive days, at dosages ranging from 1.25 to 15 mg/kg/day. Other groups of rats were dosed daily for 10 days by oral gavage with cyclophosphamide (CY) at dosages ranging from .75 to 6 mg/kg/day. These rats served as positive controls for the immune assays employed. The immune function parameters examined included the following: delayed-type hypersensitivity (DTH) and antibody responses to bovine serum albumin (BSA), primary antibody responses to sheep red blood cells (SRBC) and trinitrophenyl lipopolysaccharide (TNP-LPA), and enumeration of splenic lymphocyte populations. The DTH and antibody responses to BSA were not effected by TBTO exposure; however these responses were suppressed in rats dosed with CY at 6 mg/kg/day. The plaque forming cell (PFC) response to the T cell-dependent antigen SRBC was enhanced in rats dosed with TBTO at from 5 to 15 mg/kg/day. On the other hand, the PFC response to the T cell-independent antigen TNP-LPS was unaffected by TBTO exposure. Rats dosedwith CY had suppressed PFC responses to SRBC and TNP-LPS at dosages of 3 and 6 mg/kg/day, respectively. (Copyright (c) 1990 Elsevier Scientific Publishers Ireland Ltd.) |