| Main Title |
Age-Related Alterations in the Stimulated Release In vitro of Catecholamines and Luteinizing Hormone-Releasing Hormone from the Male Rat Hypothalamus. |
| Author |
Goldman, J. M. ;
Cooper, R. L. ;
Rehnberg, G. L. ;
Gabel, S. ;
McElroy, W. K. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Iowa Univ., Iowa City. Coll. of Medicine. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/128; |
| Stock Number |
PB88-144423 |
| Additional Subjects |
Catecholamines ;
Aging(Biology) ;
Hypothalamus ;
Norepinephrine ;
Dopamine ;
Rats ;
Tissues(Biology) ;
Reprints ;
LH-FSH releasing hormone ;
Tissue culture ;
Electric stimulation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-144423 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Using an in vitro perifusion system, the present study investigated the possibility that alterations in catecholamine and luteinizing hormone-releasing hormone (LHRH) secretion from the male rat mediobasal hypothalamus are present during the period of middle-age. The results indicate that, while tissue concentrations and baseline secretion of norepinephrine, dopamine and LHRH were similar between age groups, the patterns of dopamine and LHRH release in response to a series of depolarizing stimuli was different in the older animals. After all challenges, dopamine concentrations in the perifusate declined much more sharply for the middle-aged group, a finding that may be associated with a decrease with age in the pool of transmitter available for ready release. (Copyright (c) 1987 Plenum Publishing Corporation.) |
