Record Display for the EPA National Library Catalog


Main Title Teratogenic Effects of Trichloroacetonitrile in the Long-Evans Rat (Journal Version).
Author Smith, M. K. ; Randall, J. L. ; Tocco, D. R. ; York, R. G. ; Stober, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Cincinnati, OH. ;Computer Sciences Corp., Cincinnati, OH.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/192;
Stock Number PB89-119796
Additional Subjects Teratogens ; Toxicity ; Drinking water ; Water pollution ; Concentration(Composition) ; Laboratory animals ; Nitriles ; Chlorine organic compounds ; Cardiovascular system ; Urogenital system ; Reprints ; Trichloroacetonitrile ; Acetonitrile/trichloro
Library Call Number Additional Info Location Last
NTIS  PB89-119796 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Trichloroacetonitrile (TCAN) is among a number of contaminants found in drinking water produced by reactions of chlorine with background organic material. Long-Evans rats were incubated with TCAN on gestation days 6-18. The highest dose tested (55 mg/kg) was lethal in 21% of the dams and produced 100% resorptions in two-thirds of the survivors. Only one maternal death was seen at the next-lower dose; however, fetal weight and viability were decreased in a dose-related manner. The percentage of embryolethality was 13.9% at the lowest dose (1 mg/kg) and 78.4% at the high dose, with resorption of entire litters seen at 7.5 mg/kg and above. At all doses, cardiovascular (interventricular septal defect, levocardia, common carotid, and right-sided aortic arch and ductus arteriosus) and urogenital (hypoplastic, missing, misplaced and fused kidneys, and hypoplastic uterine horns) malformations were seen in the offspring. Frequency of these malformations was dose related. The incidence of total soft tissue malformations was statistically significant at 15 and 35 mg/kg. (Copyright (c) 1988 Alan R. Liss, Inc.)