Application of water-based cleaners with hand-pumped sprayers may result in exposure to both gas-phase contaminants and aerosols. Tests were performed in a controlled-environment test room to measure particle concentrations and size distributions and concentrations of selected volatile organic compounds during, and following, application of water-based cleaners to realistic surfaces. The particle size distribution, during the application of a more diluted cleaner shifted toward the smaller sizes and the concentrations of the fine particles decreased slowly at low exchange rates. Results of the particle concentration and size distribution measurements are presented and discussed as they relate to the concentration of the cleaner and room air exchange rate. The results are used to estimate the depletion rate of the droplets during the tests.