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Main Title Introduction and Study Design (Evaluation of Four Plant Bioassays for Detecting Genetic Hazards of Environmental Chemicals).
Author Sandhu, S. S. ; de Serres, F. J. ; Gopalan, H. N. B. ; Grant, W. F. ; Veleminsky, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Research Triangle Inst., Research Triangle Park, NC. ;United Nations Environment Programme, Nairobi (Kenya). ;Institute of Experimental Botany, Prague (Czech Republic). ;World Health Organization, Research Triangle Park, NC. International Programme on Chemical Safety.
Publisher c1994
Year Published 1994
Report Number EPA/600/J-94/525;
Stock Number PB95-148870
Additional Subjects Bioassay ; Plants(Botany) ; Environmental effects ; Toxic substances ; Pollutant identification ; Chemical compounds ; Standards ; Validation ; Mutagens ; Genetics ; International cooperation ; Chlorophyll ; Azides ; Sulfur compounds ; Nitroso compounds ; Sodium azides ; Reprints ; Tradescantia micronucleus assay ; Vicia faba root tip assay ; Arabidopsis thaliana embryo ; Maleic hydrazide ; Urea/N-methyl-N-nitroso ; Methane sulfonate/ethyl ; Glycerol/azido
Library Call Number Additional Info Location Last
NTIS  PB95-148870 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Under the sponsorship of the UNEP/ILO/IPCS, 17 laboratories from diverse regions of the world participated in evaluating the utility of four plant bioassays for detecting genetic hazards of environmental chemicals. The bioassays included in this collaborative study were Arabidopsis embryo and chlorophyll assay and Tradescantia stamen hair assay. Tradescantia micronucleus assay, and Vicia faba root tip assay. Four to six laboratories participated in the conduction of each of the bioassays. All laboratories participating in a particular bioassay were supplied with uniform plant material as well as a standardized protocol. Five direct acting water soluble test chemicals, i.e., maleic hydrazide, methyl nitrosourea, ethyl methanesulfonate, sodium azide, and azidoglycerol were selected for this study. The study was designed to be completed in three phases. Ethyl methanesulfonate was used as a positive control and has already been reported earlier (Sandhu et al., 1991). The data from the remaining four chemicals used for the evaluation of four plant test systems in first phase of the collaborative study are reported in this volume. (Copyright (c) 1994 Elsevier Science B.V.)