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Main Title Arabidopsis Assay for Mutagenicity.
Author Gichner, T. ; Badayev, S. A. ; Demchenko, S. I. ; Relichova, J. ; Sandhu, S. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Office of Health Research. ;Institute of Experimental Botany, Prague (Czech Republic). ;Akademiya Nauk SSSR, Moscow. Inst. Fizicheskoi Khimii. ;Akademiya Nauk Tadzhikskoi SSR, Dushanbe. Dept. of Genetics.
Publisher c1994
Year Published 1994
Report Number EPA/600/J-94/523;
Stock Number PB95-148854
Additional Subjects Bioassay ; Plants(Botany) ; Pollutant identification ; Toxic substances ; Environmental effects ; International cooperation ; Chemical compounds ; Mutagens ; Sodium azides ; Validation ; Azides ; Sulfur compounds ; Nitroso compounds ; Reprints ; Arabidopsis assay ; Methane sulfonate/ethyl ; Ureo/N-methyl-N-nitroso ; Glycerol/azido ; Maleic hydrazide
Library Call Number Additional Info Location Last
NTIS  PB95-148854 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Four laboratories, two in Czechoslovakia (Brno and Prague) and two in USSR (Moscow and Duschanbe), participated in the International Program On Chemical Safety (IPCS) Collaborative Study to evaluate the utility of the most commonly used plant test systems, including the Arabidopsis thaliana assay, for assessing the mutagenic potential of environmental agents. Out of the five compounds evaluated in the Arabidopsis assay, 3 compounds; i.e., ethyl methanesulfonate, N-methyl-N-nitrosourea, and 3-azidoglycerol, were reported by all four participating laboratories to be mutagenic. Sodium azide (NaN3) demonstrated negative response in all four laboratories; whereas, maleic hydrazide was reported to be weakly mutagenic by one laboratory and no mutagenic response by the other three laboratories. (Copyright (c) 1994 Elsevier Science B.V.)