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Main Title Multifactor Potency Scheme for Comparing the Carcinogenic Activity of Chemicals.
Author Nesnow, S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/185;
Stock Number PB92-188911
Additional Subjects Carcinogens ; Toxicity ; Mice ; Rats ; Dose-response relationships ; Tissue distribution ; Sex factors ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-188911 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
A scheme for ranking the quantitative activity of chemical carcinogens is described. The activity scheme uses as its base, dose potency measured as TD50, which after conversion into an inverse log scale, a decile scale, is adjusted by weighting factors that describe other parameters of carcinogenic activity. These factors include positive or negative weightings for: the induction of tumors at tissues or organs associated with high historical control tumor incidences; the induction of tumors at multiple sites; the induction of tumors in both sexes of the species; and the induction of tumors in more than one species. These factors were chosen as they represented qualitative descriptions of the general specificity or non-specificity of chemicals with regard to the activity in rodents and have some bearing on the potential activity of chemicals in humans. In order to construct a measure to express the inactivity of chemicals towards the induction of cancer, a measure analogous to the TD50 has been developed: the highest average daily dose (HADD) in mg chemical/kg body weight administered in a chronic cancer study and that did not induce a statistical increase in tumors. HADD values were similarly converted to log decile units and adjusted by weighting factors according to lack of activity in both sexes of a species, and the lack of activity in more than one species.