Record Display for the EPA National Library CatalogRECORD NUMBER: 1 OF 12
|Main Title||5,7-Dihydroxytryptamine Injections Increase Glial Fibrillary Acidic Protein in the Hypothalamus of Adult Rats.|
|Author||Frankfurt, M. ; O'Callaghan, J. ; Beaudet, A. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Rockefeller Univ., New York. Lab. of Neuroendocrinology. ;Montreal Neurological Inst. (Quebec). Neuroanatomy Lab.|
|Additional Subjects||Glial fibrillary acidic protein ; Hypothalamus ; 5-7-dihydroxytryptamine ; Rats ; Astrocytes ; Serotonin ; Radioimmunoassay ; Immunohistochemistry ; Reprints ;|
The distribution and level of glial fibrillary acidic protein (GFAP) were determined in the adult rat hypothalamus following axotomy of serotonin (5-HT) neurons. Seven days after unilateral intrahypothalamic injection of the 5-HT neurotoxic, 5,7-dihydroxytryptamine, there was a marked increase in the number of GFAP-labelled astrocytes in the ipsilateral hypothalamus of 5,7-DHT-treated as compared to sham-treated rats. Measurement of GFAP levels demonstrated a significant increase on the ipsilateral side of 5,7-DHT-treated rats as compared to sham-treated rats.