Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Trimethyltin on Dopaminergic and Serotonergic Function in the Central Nervous System.
Author DeHaven, D. L. ; Walsh, T. J. ; Mailman, R.B. ;
CORP Author North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-809644; EPA/600/J-84/328;
Stock Number PB86-117231
Additional Subjects Central nervous system ; Toxicology ; Brain ; Dopamine ; Serotonin ; Rats ; Laboratory animals ; Reprints ; Tin/trimethyl ; Metabolites
Library Call Number Additional Info Location Last
NTIS  PB86-117231 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 9p
The effects of trimethyltin (TMT) administration on regional concentrations of dopamine (DA), serotonin (5-HT), and their metabolites were determined. Acute administration of 3 or 7 mg/kg TMT (as the chloride) to adult male Long-Evans rats caused alterations in both dopaminergic and serotonergic function in brain at 7 days posttreatment. Dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were decreased in the nucleus accumbens of rats treated with 7 mg/kg, with a trend occurring with the 3-mg/kg dose group. Conversely, concentrations of DA or DOPAC were not altered in striatum, olfactory tubercle, septum, or amygdala/pyriform cortex. Administration of 3 mg/kg TMT decreased the concentration of serotonin in striatum and nucleus accumbens, and increased the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in hippocampus. The 7-mg/kg dose resulted in increased concentrations of 5-HIAA in striatum, nucleus accumbens, septum, amygdala/pyriform cortex, and hippocampus, and also decreased the concentration of 5-HT only in amygdala/pyriform cortex.