Record Display for the EPA National Library Catalog


Main Title Effects of chlordimeform on vascular tissue /
Author Robinson, Casey P.
Other Authors
Author Title of a Work
Charles, Jeffrey.
CORP Author Oklahoma Univ. Health Sciences Center, Oklahoma City.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1979
Report Number EPA-600/1-79-031; EPA-R-804975
Stock Number PB80-116817
OCLC Number 47899459
Subjects Acaricides--Health aspects ; Acaricides--Physiological effect
Additional Subjects Pesticides ; Toxicology ; Chlorine organic compounds ; Concentration(Composition) ; Exposure ; Physiological effects ; Dogs ; Laboratory animals ; Experimental data ; In vitro analysis ; Cardiovascular system ; Muscles ; Arteries ; Serotonin ; Phentolamine ; Chlordimeform ; Formamidine/N-(chloro-tolyl)-N-N-dimethyl ; Toxic substances ; Metabolites
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-79-031 Headquarters Library/Washington,DC 04/18/2014
EKBD  EPA-600/1-79-031 Research Triangle Park Library/RTP, NC 09/07/2001
ELBD ARCHIVE EPA 600-1-79-031 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD RPS EPA 600-1-79-031 repository copy AWBERC Library/Cincinnati,OH 10/17/2014
NTIS  PB80-116817 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xiii, 50 p. : ill., charts ; 28 cm.
In order to fully understand potential risk to human beings of exposure to a chemical, one needs to understand the effects of that chemical upon each organ system and to determine its mode of action. For some classes of pesticides their primary mode of toxicity has been established. An example of this is the organophosphorus cholinesterase inhibitors. There is general agreement that their acute lethality and most of their toxicities result from cholinesterase inhibition and subsequent acetylcholine accumulation. Even among this group of compounds, however, there are toxic effects which seem to be due to other actions. For other classes of compounds much less is known of their mechanisms of lethality and effects on organ systems. An example of this is the formamidines, the first useful one of which was chlordimeform. Little information on the mode of action of chlordimeform was available, and on its other effects. This study was initially proposed to determine vascular actions of chlordimeform. The project was expanded to examine the cardiovascular actions of other available formamidines including formamidine metabolites which also retained the formamidine structure.
EPA project officer: Jeffrey Charles. Prepared by University of Oklahoma, Health Sciences Center for U.S. Environmental Protection Agency. "EPA-600/1-79-031"--Cover. "August 1979"--Cover. "Jeffrey Charles Health Effects Research Laboratory, Environmental Protection Agency"--T.p. Includes bibliographical references.