Record Display for the EPA National Library Catalog


Main Title Symposium Overview: Advances in Biologically Based Models for Respiratory Tract Uptake of Inhaled Volatiles.
Author Medinsky, M. A. ; Kimbell, J. S. ; Morris, J. B. ; Gerde, P. ; Overton, J. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;Connecticut Univ., Storrs. Dept. of Renewable Natural Resources. ;National Inst. of Occupational Health, Solna (Sweden).
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/335;
Stock Number PB93-229532
Additional Subjects Dose-response relationships ; Respiratory tract ; Pharmacokinetics ; Respiratory airflow ; Biochemistry ; Metabolism ; Absorption ; Risk assessment ; Toxicity ; Models ; Reprints ; Volatile organic compounds
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB93-229532 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Physiologically based pharmacokinetic models for volatile organic chemicals typically describe the respiratory tract as a single compartment in which chemicals in the alveolar air space and the arterial blood are in instantaneous equilibrium. A functional role for the upper respiratory tract in the uptake of volatile chemicals has been largely ignored. Airflow patterns in the respiratory tract, regional metabolism, diffusion-dependent uptake, and the cyclic nature of respiration are now being incorporated into current models. Use of dosimetric models that incorporate relevant biology for inhaled chemicals will ultimately result in more meaningful human risk assessments. (Copyright (c) 1993 Society of Toxicology.)