Record Display for the EPA National Library Catalog


Main Title Range Finding Tests on Acrylamide with Cover Letter.
CORP Author Union Carbide Corp., Danbury, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 22 Sep 1947
Year Published 1947
Report Number 878212200;
Stock Number OTS-0206058
Additional Subjects Toxicity ; Rats ; Laboratory animals ; Lethal doses ; Ingestion ; Exposure ; Eye irritation ; Rabbits ; Toxicology ; Range finding tests ; Acrylamide ; CAS No 79-06-1
Library Call Number Additional Info Location Last
NTIS  OTS-0206058 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Acrylamide is a highly toxic compound as evidenced by an R.F. LD50 of 0.316 gm./kg. for rats by the oral route. It has the same order of acute toxicity as propylene chlorhydrin, and approximately 8 times that of acrylic acid, 10 times that of formamide, and 100 times that of acetamide. Skin penetration studies were not carried out because of the solid nature of the compound. A mist exposure was abruptly terminated when the compound polymerized in the bubbler held at 170 degrees C. No rats died as a result of the 30 minute exposure that was completed. Acrylamide as a 40% solution in acetone is non-irritant to rabbit skin and a 10% solution in propylene glycol does not damage rabbit eyes. Aside from the dangers of ingestion, this compound should not present any great hazard to persons handling it, unless it should prove to be a powerful sensitizer.