Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Assessment of Neurotoxicity: Use of Glial Fibrillary Acidic Protein as a Biomarker.
Author O'Callaghan, J. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/249;
Stock Number PB92-110527
Additional Subjects Nervous system ; Toxicity ; Biological markers ; Glial fibrillary acidic protein ; Astrocytes ; Radioimmunoassay ; Toxic substances ; Hippocampus ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-110527 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 02/24/1992
Collation 12p
Diverse neurotoxic insults results in proliferation and hypertrophy of astrocytes. The hallmark of this response is enhanced expression of the major intermediate filament protein of astrocytes, glial fibrillary acidic protein (GFAP). These observations suggest that GFAP may be a useful biomarker of neurotoxicity. To investigate this possibility, the authors administered prototype neurotoxicants to experimental animals and assessed the effects of these agents on the tissue content of GFAP, as determined by radioimmunoassay. A review of the background, design and results of these experiments are presented in the paper. Study findings indicate that radioimmunoassay of GFAP is a sensitive and specific biomarker of neurotoxicity.