Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Assessment of Implantation in the Rat.
Author Cummings, A. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1991
Year Published 1991
Report Number EPA/600/D-91/283;
Stock Number PB92-126903
Additional Subjects Ovum implantation ; Toxic substances ; Rats ; Teratogenic compounds ; Embryo ; Reproduction(Biology) ; Animal pregnancy ; Hormones ; Radioimmunoassay ;
Library Call Number Additional Info Location Last
NTIS  PB92-126903 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 02/24/1992
Collation 12p
A series of protocols has been assembled and used for the assessment of implantation failure following chemical exposure in the rat. Upon detecting a chemically-induced blockade of implantation, these protocols are designed to probe the physiological mechanisms through which the chemical may impair early pregnancy, including a distinction between embryotoxicity and maternal reproductive toxicity. The protocols include the early pregnancy protocol, the decidual cell response technique, the pre-vs. postimplantation protocol, and the embryo transport rate analysis. These protocols are simple and rapid and provide considerable information regarding the effects of chemicals on the processes involved during embryo implantation.