Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Chlorine Dioxide on the Developing Rat Brain.
Author Toth, G. P. ; Long, R. E. ; Mills, T. S. ; Smith, M. K. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Pathology Associates, Inc., West Chester, OH. ;Computer Sciences Corp., Cincinnati, OH.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/329;
Stock Number PB91-149757
Additional Subjects Toxicity ; Brain ; Rats ; Deoxyribonucleic acids ; Synapses ; Histopathology ; Thyroid hormones ; Organ weight ; Body weight ; Liver mitochondria ; Glycerolphosphate dehydrogenase ; Radioimmunoassay ; Reprints ; Chlorine dioxide
Library Call Number Additional Info Location Last
NTIS  PB91-149757 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/13/1991
Collation 19p
Male and female Long-Evans rat pups, exposed to an oral dose of 14 mg chlorine dioxide ClO2/Kg/d (postnatal d 10), were examined for effects on brain development and for changes in thyroid activity. Body weight reductions were observed on postnatal (pn) d 11, 21, and 35. Forebrain weight and protein content were decreased on pnd 21 and 35, as were the DNA content on d 35 and the number of dendritic spines on cerebral cortical pyramidal cells, a marker for synapse formation. Otherwise, cell proliferation in the forebrain, cerebellum, and olfactory bulbs was normal, as were migration and aggregation of neuronal cells in three areas of the cerebral cortex. Histopathology of the forebrain, cerebellum, and brainstem showed no gross lesions loss of myelin, or change in the cells staining positive for Nissl substance. Serum T3 and T4 levels, as well as hepatic mitochondrial alpha-glycerophosphate dehydrogenase activity, were unchanged by ClO2 treatment. The results indicated that ClO2 may have central neurotoxic potential. No underlying antithyroid activity was evident.