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Main Title Acute Effects of Ozone on Heart Rate and Body Temperature in the Unanesthetized, Unrestrained Rat Maintained at Different Ambient Temperatures.
Author Watkinson, W. P. ; Aileru, A. A. ; Dowd, S. M. ; Doerfler, D. L. ; Tepper, J. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/089;
Stock Number PB93-175586
Additional Subjects Ozone ; Air pollution effects(Animals) ; Body temperature ; Heart rate ; Rats ; Anesthesia ; Temperature ; Radio telemetry ; Electrocardiography ; Dose-response relationships ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-175586 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
The present studies were conducted to investigate the concentration-response characteristics of acute ozone (O3) exposure on the cardiovascular and thermoregulatory function of the unanesthetized, unrestrained rat, and to examine the modulating effects produced by changes in ambient temperature (T(sub a)) on the induced toxic response. For all studies, groups of male Fischer 344 rats (n=4-6/group) were implanted with radiotelemetry transmitters and allowed to recover overnight. The transmitters permitted continuous monitoring of electrocardiogram (ECG) and body core temperature (T(sub co)); heart rate (HR) was derived from the ECG signal. Frequency of breathing (f) was obtained in selected experiments by means of a Fenn box. All animals were monitored according to the following protocol: control (filtered air; 0.25 h); exposure (O3; 2 h); recovery (filtered air; 3-18 h). For the concentration-response experiments, O3 concentration was varied from 0.25-1.0 ppm and all exposures were conducted at an T(sub a) of 18-20 C. Significant decreases in HR and T(sub co) were demonstrated at O3 concentrations as low as 0.37 ppm.