Record Display for the EPA National Library Catalog


Main Title Lung function and its growth /
Other Authors
Author Title of a Work
Collier, Albert M.
Ketcham, Brock.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1977
Report Number EPA-600/1-77-044; EPA-R-902233
Stock Number PB-276 632
OCLC Number 52418696
Additional Subjects Respiratory diseases ; Infectious diseases ; Immunity ; Viral diseases ; Children ; Infants ; Lung ; Pathophysiology ; Etiology ; Air pollution effects(Humans) ; Lung function tests ; Respiratory syncytial virus ; Airway obstruction ; Airway resistance ; Pulmonary function
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-77-044 Headquarters Library/Washington,DC 05/19/2014
EKBD  EPA-600/1-77-044 Research Triangle Park Library/RTP, NC 06/13/2003
ELBD ARCHIVE EPA 600-1-77-044 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD RPS EPA 600-1-77-044 repository copy AWBERC Library/Cincinnati,OH 07/07/2016
NTIS  PB-276 632 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation ix, 23 pages ; 28 cm.
Evidence that certain uncomplicated upper respiratory infections (URI) induce pulmonary function abnormalities in adults prompted a study in children where such infections occur more frequently. In a longitudinal study, 55 children aged 2.5-9 years were observed for a mean duration of 2 years. Spirometry and lung volume studies were obtained routinely every 3 months, with each URI and 4 weeks post-illness providing data on 636 well and 260 illness observations. Adjusted mean values of forced vital capacity, 1 sec forced expiratory volume, peak expiratory flow rate, mid-maximal expiratory flow rate, and expiratory flow rate at 50% FVC decreased during URI. The data suggest lower respiratory tract involvement without signs or symptoms of lower airways or alveolar disease occurs with URI of varied etiology in childhood. Respiratory syncytial virus is the most common cause of severe lower respiratory illness in infants and recurrent infections occur commonly. To evaluate the immune response to primary and secondary RSV infection serial determinations of serum neutralizing antibody and circulating antigen reactive lymphocytes were performed. Although a brisk serum antibody response was seen after both infections, antigen reactive lymphocytes were only detected after the second episode.
Project Officer: Brock Ketcham. University of North Carolina School of Medicine, Frank Porter Graham Child Development Center "September 1977." "EPA-600/1-77-044." Includes bibliographical references.