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Main Title Effects of Triadimefon on a Multiple Schedule of Fixed-Interval Performance: Comparison with Methylphenidate, d-Amphetamine and Chlorpromazine.
Author Allen, A. R. ; MacPhail., R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Univ. at Chapel Hill.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/021;
Stock Number PB92-143932
Additional Subjects Fungicides ; Toxicity ; Psychomotor performance ; Methylphenidate ; Amphetamines ; Chlorpromazine ; Comparison ; Rats ; Motor activity ; Dose-response relationships ; Reprints ; Triadimefon
Library Call Number Additional Info Location Last
NTIS  PB92-143932 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
The experiment was designed to compare triadimefon to known psychomotor stimulants. Four rats were trained to perform under a mult FI 1-min FI 5-min schedule of milk reinforcement. They then received a series of dosages of triadimefon (10-170 mg/kg, i.p.) and of methylphenidate (1-17.3 mg/kg, i.p.) in a counterbalanced order. Certain dosages of triadimefon increased response rates for all rats in the FI 1-min component and in the FI 5-min component. Methylphenidate increased response rates in each component for only two rats. Temporal patterns of responding were disrupted more in the FI 5-min component than in the FI 1-min component by both triadimefon and methylphenidate. Performances were then evaluated following a series of dosages of d-amphetamine (0.3-3.0 mg/kg, i.p.) and chlorpromazine (0.5-2.0 mg/kg, i.p.). Response rates in FI 1-min were increased by d-amphetamine for three rats and in FI 5-min for two rats. d-Amphetamine, like triadimefon and methylphenidate, produced a greater disruption of response patterning in FI 5-min than in FI 1-min. Chlorpromazine only decreased response rates, but also produced some disruption in FI 5-min response patterning.