Record Display for the EPA National Library Catalog


Main Title Cerebellar Hypoplasia in the Gunn Rat is Associated with Quantitative Changes in Neurotypic and Gliotypic Proteins.
Author O'Callaghan , J. P. ; Miller, D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/410;
Stock Number PB86-214871
Additional Subjects Proteins ; Bioassay ; Rats ; Laboratory animals ; Morphology ; Behavior ; Reprints ; Neurotoxicity ; Cerebellar hypoplasia
Library Call Number Additional Info Location Last
NTIS  PB86-214871 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
The authors are characterizing toxicant-induced injury to the nervous system by measuring nervous system cell-type specific proteins together with accompanying changes in morphology and behavior. In the present study, cerebellar neurotoxicity was assessed in the Gunn rat an autosomal recessive mutant that exhibits degeneration of Purkinje cells due to hereditary hyperbilirubinemia. Five proteins associated with neuronal or glial cell types were chosen for evaluation as follows: (1) G-substrate, a Purkinje cell-specific phosphoprotein that serves as the endogenous substrate of cyclic GMP-dependent protein kinase; (2) PCPP-260, a Purkinje cell-specific phosphoprotein that serves as an endogenous substrate of cyclic AMP-dependent protein kinase; (3) synapsin I, a synapse-specific phosphoprotein present in all neurons; (4) glial fibrillary acidic protein, an astrocyte-specific protein; and (5) myelin basic protein, a protein unique to myelin.