Record Display for the EPA National Library Catalog

RECORD NUMBER: 9 OF 20

OLS Field Name OLS Field Data
Main Title Nasal Lavage as a Tool in Assessing Acute Inflammation in Response to Inhaled Pollutants.
Author Koren, H. S. ; Hatch, G. E. ; Graham., D. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/161;
Stock Number PB91-115881
Additional Subjects Nose(Anatomy) ; Ozone ; Inflammation ; Respiration ; Reprints ; Air pollution effects(Humans) ; Bronchoalveolar lavage fluid ; Complement 3a ; Prostaglandins ; Neutrophils ; Acute disease ; Plasminogen activators ; Biological markers
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-115881 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 13p
Abstract
The study addresses the effect of an acute (2 hour) exposure of ozone at 0.4 ppm on the inflammatory response in the upper airways of 10 normal volunteers and compared these results to those obtained in the lower airways assessed by bronchoalveolar lavage (BAL). The results indicate significant increases in the number of polymorphonuclear neutrophils (PMN) in NAL immediately post exposure (7.7-fold). This increase is still detectable 18 hours post exposure (6-fold) which is similar to the increase of PMN in BAL. The albumin level, which is an indicator of epithelial cell permeability, was elevated 18 hours post exposure (1.5 fold). Interestingly, several other markers of acute inflammation such as prostaglandin E2 (PGEalpha), C3a, urokinase-type plasminogen activator (U-PA), which were found to be significantly elevated in the BAL of the same group of subjects (18 hours post exposure), were not elevated in the NAL either immediately post or 18 hours post exposure. Collectively the data suggest that NAL may serve as a sensitive and reliable technique to detect inflammation in the upper airways of subjects exposed to ozone.