Record Display for the EPA National Library Catalog


Main Title Cancer Dose-Response Models Incorporating Clonal Expansion.
Author Chen, C. W. ; Moini, A. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. ;Computer Sciences Corp., Arlington, VA.
Publisher Oct 89
Year Published 1989
Report Number EPA/600/D-91/042 ;OHEA-C-330;
Stock Number PB91-171975
Additional Subjects Carcinogenesis ; Dose-response relationships ; Mathematical models ; Risk factors ; Predictive value of tests ;
Library Call Number Additional Info Location Last
NTIS  PB91-171975 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 26p
Under the assumption that a malignant tumor develops through a sequence of steps (normal cells->initiated cells/foci->nodules->tumors) two classes of mathematical models of carcinogenesis that have a potential to be used for cancer dose-response modeling are discussed. The two classes of models considered are (1) a general version of the two-stage model by Moolgavkar and colleagues, henceforth called the MVK model, and (2) a clone process model derived from Tucker. These two classes of models incorporate essentially the same biological information but in different ways and offer a conceptual contrast between the two differing approaches. The objectives of the paper are to (1) highlight issues and problems that arise in using biologically based dose-response models to predict cancer risk and (2) discuss how parameters in the models could be estimated using auxiliary information.