Record Display for the EPA National Library Catalog


Main Title Synergistic effect of polonium-210 and cigarette smoke in rats /
Author Black, Stuart C., ; Bretthauer., E. W.
CORP Author National Environmental Research Center, Las Vegas, Nev. Monitoring Systems Research and Development Lab.
Publisher National Environmental Research Center,
Year Published 1975
Report Number EPA-680/1-75-001; ROAP 21AMC; 1FA082
Stock Number PB-246 174
OCLC Number 01986430
Subjects Polonium--Physiological aspects ; Lungs--Cancer ; Lung Neoplasms--etiology ; Neoplasms, Experimental
Additional Subjects Polonium 210 ; Smoking ; Radiation effects ; Radioactive isotopes ; Rats ; Laboratory animals ; Experimental data ; Exposure ; Lung ; Neoplasms ; Respiratory diseases ; Bronchitis ; Pathology ; Cigarette smoking ; Synergistic effects of air pollution ; Carcinogenesis
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 680-1-75-001 Headquarters Library/Washington,DC 06/10/2015
EKBD  EPA-680/1-75-001 Research Triangle Park Library/RTP, NC 09/09/2016
ELBD ARCHIVE EPA 680-1-75-001 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB-246 174 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation v, 12 pages : illustrations ; 27 cm
An experimental procedure was devised to test the possible synergistic effect of polonium-210 and cigarette smoke in rats. Appropriate techniques were developed to expose the rats to cigarette smoke through mouth-breathing and to add known amounts of polonium-210 to the cigarette smoke. The findings from this experiment included: (1) lung deposition of polonium-210 was 31 plus or minus 2%, (2) early retention of polonium was two-phased with half-times of 4 and 84 hours, and (3) bronchitis, emphysema and lung tumors were observed in the experimental animals. Though the spontaneous occurrence of two lung tumors in the number of animals at risk was highly improbable, any conclusion that this resulted from the exposure to cigarette smoke must be highly qualified.
ROAP 21AMC Program element 1FA082. Includes bibliographical references (pages 11-12).