| Main Title |
Synergistic effect of polonium-210 and cigarette smoke in rats / |
| Author |
Black, Stuart C., ;
Bretthauer., E. W.
|
| CORP Author |
National Environmental Research Center, Las Vegas, Nev. Monitoring Systems Research and Development Lab. |
| Publisher |
National Environmental Research Center, |
| Year Published |
1975 |
| Report Number |
EPA-680/1-75-001; ROAP 21AMC; 1FA082 |
| Stock Number |
PB-246 174 |
| OCLC Number |
01986430 |
| Subjects |
Polonium--Physiological aspects ;
Lungs--Cancer ;
Lung Neoplasms--etiology ;
Neoplasms, Experimental
|
| Additional Subjects |
Polonium 210 ;
Smoking ;
Radiation effects ;
Radioactive isotopes ;
Rats ;
Laboratory animals ;
Experimental data ;
Exposure ;
Lung ;
Neoplasms ;
Respiratory diseases ;
Bronchitis ;
Pathology ;
Cigarette smoking ;
Synergistic effects of air pollution ;
Carcinogenesis
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EIAD |
EPA-680/1-75-001 |
|
Region 2 Library/New York,NY |
03/18/2005 |
DISPERSAL |
| EJBD ARCHIVE |
EPA 680-1-75-001 |
|
Headquarters Library/Washington,DC |
05/28/2013 |
| EJBD |
EPA 680-1-75-001 |
|
Headquarters Library/Washington,DC |
06/10/2015 |
| EKBD |
EPA-680/1-75-001 |
|
Research Triangle Park Library/RTP, NC |
09/09/2016 |
| NTIS |
PB-246 174 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
v, 12 pages : illustrations ; 27 cm |
| Abstract |
An experimental procedure was devised to test the possible synergistic effect of polonium-210 and cigarette smoke in rats. Appropriate techniques were developed to expose the rats to cigarette smoke through mouth-breathing and to add known amounts of polonium-210 to the cigarette smoke. The findings from this experiment included: (1) lung deposition of polonium-210 was 31 plus or minus 2%, (2) early retention of polonium was two-phased with half-times of 4 and 84 hours, and (3) bronchitis, emphysema and lung tumors were observed in the experimental animals. Though the spontaneous occurrence of two lung tumors in the number of animals at risk was highly improbable, any conclusion that this resulted from the exposure to cigarette smoke must be highly qualified. |
| Notes |
ROAP 21AMC Program element 1FA082. Includes bibliographical references (pages 11-12). |
