Record Display for the EPA National Library Catalog


Main Title Tissue Organ Distribution and Behavioral Effects of Platinum Following Acute and Repeated Exposure of the Mouse to Platinum Sulfate.
Author Lown, Bradley A. ; Morganti, John B. ; Stineman, Carl H. ; D'Agsotino, Rosemary B. ; Massaro, Edward J. ;
CORP Author Pennsylvania State Univ., University Park. Center for Air Environment Studies.;Environmental Protection Agency, Washington, DC.
Year Published 1980
Report Number EPA-600/J-80-099;
Stock Number PB81-118937
Additional Subjects Platinum ; Toxicology ; Ingestion(Biology) ; Bioassay ; Mice ; Laboratory animals ; Metals ; Lethal dosage ; Behavior ; Tissues(Biology) ; Sodium chloride ; Platinum inorganic compounds ; Reprints ; Platinum sulfate ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB81-118937 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Platinum sulfate was administered intragastrically (IG) to adult male Swiss mice in a single dose at the 7 day LD5 or LD25 level. Control groups received 0.25M H2SO4 (pH 0.85) or 0.14M NaCl. Open field behavior (ambulations, rearings) was measured, and tissue/organ Pt levels determined at 4 hr, or 1, 3, or 7 days post administration. At all times, the LD25 depressed ambulations significantly and rearings marginally. It did not effect exploratory ('hole-in-board') behavior. The LD25 resulted in disproportionately high tissue Pt levels relative to the LD5. There were significant inverse correlations between behavior and tissue Pt levels for most tissues, but not for brain. In related experiments, adult male mice were subjected to repeated IG administration of PT(SO4)2 at the LD1 level (one dose every 72 hr for up to 10 doses). Three days after administration of the final dose of each series, open-field and exploratory performance were measured and tissue/organ Pt levels determined. Tissue/organ Pt levels were variable but generally increased with dose number. No Pt was detected in the brain. Activity and explorations were marginally depressed. Only rearings correlated significantly with tissue Pt levels.