Record Display for the EPA National Library Catalog


Main Title Physical Factors Affecting Lung Deposition of Cigarette Smoke (with Syncarcinogenic Radon Progeny Effects), and Mineral Fiber Particulate Matter.
Author Martonen, T. B. ; Hofmann, W. ; Balashazy, I. ;
CORP Author Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher Nov 88
Year Published 1988
Report Number EPA-68-02-4450; EPA/600/D-88/266;
Stock Number PB89-130454
Additional Subjects Toxicology ; Air pollution ; Smoke ; Mineral wool ; Lung ; Radon ; Particles ; Mathematical models ; Respiration ; Pathology ; Aerosols ; Carcinogens ; Reprints ; Cigarette smoke ; Risk assessment ; Inhalation administration
Library Call Number Additional Info Location Last
NTIS  PB89-130454 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 43p
Unusual dynamic factors affecting the behavior and fate of inhaled cigarette-smoke particles and mineral fibers within the human lung are addressed. The actions of interception, for fiber particles, and cloud-settling, for concentrated cigarette smoke, can enhance focal deposition in locations that would not have been anticipated for dilute aerosols or for more regularly shaped, sphere-like particles. It is important to quantitate the efficiencies of these deposition mechanisms because it is after deposition that deleterious biological effects can occur. Theoretical deposition models are presented that simulate the actions of the interception and cloud-settling processes, which are validated by comparisons with in vitro and in vivo data. The sites of preferential deposition are regions whose cells receive increased doses of hazardous substances associated with smokes and fibers. They must, therefore, be considered in risk assessment analyses of human inhalation exposures to airborne toxicants. Incorporation of these mechanisms in aerosol therapy protocols could conceivably lead to improved therapeutic procedures.