|Chloroform Induction of Ornithine Decarboxylase Activity in Rats.
Savage, Jr., Russell E. ;
Westrich, Carol ;
Guion, Charles ;
Pereira, Michael A. ;
|Health Effects Research Lab., Cincinnati, OH.
Malignant neoplasms ;
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Chloroform is a drinking water contaminant that has been demonstrated to be carcinogenic to mice and rats resulting in an increased incidence of liver and kidney tumors, respectively. The mechanism of chloroform carcinogenicity might be by tumor initiation and/or promotion. Since induction of ornithine decarboxylase (ODC) activity has been proposed as a molecular marker for tumor promoters, the authors have investigated the effect of chloroform on ODC activity in rats.