This report includes the results of five toxicological studies of pesticide compounds conducted by the Institute for Medical Research and Occupational Health, Zagreb, Yugoslavia. In the first study, the reactions of two groups of esterases (cholinesterases and arylesterases) with substrates and inhibitors were investigated. Procedures for monitoring the absorption of phosalone and malation in occupationally exposed workers by determination of pesticide residues in the urine were developed in the second study. This detection technique was compared to the traditional blood cholinesterase inhibition method to determine which was a more rapid detector of poisoning. The third study reported surveyed the residues of chlorinated hydrocarbons in human milk and blood samples taken from the general population, and compared the levels with those found in the serum of workers exposed to pesticides. In the fourth study, cholinesterase activity was used to assess the effects of recent changes made in the protective procedures for occupationally exposed workers. Finally, in the last study, the alleged effect of pesticides on the eye and on vision were studied and the results discussed. In addition, the report also includes summaries of seven student's theses related to the work conducted by the Institute.

"PB82-226077" "EPA-600/1-82-001" "February 1982." "Grant No. R 804539010" "Project Officer: William F. Durham."