Record Display for the EPA National Library Catalog


Main Title Dose Response of 'Cryptosporidium parvum' in Outbred Neonatal CD-1 Mice.
Author Finch, G. R. ; Daniels, C. W. ; Black, E. K. ; Schaefer, F. W. ; Belosevic, M. ;
CORP Author Environmental Protection Agency, Cincinnati, OH. Risk Reduction Engineering Lab. ;Alberta Univ., Edmonton.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-94/089;
Stock Number PB94-146289
Additional Subjects Dose-response relationships ; Biological models ; Cryptosporidium parvum ; Parasitic diseases ; Dosage ; Mice ; Oocysts ; Biological effects ; Oral administration ; Water supply ; Disinfectants ; Public health ; Drinking water ; Water treatment ; Reprints ; Infective dose
Library Call Number Additional Info Location Last
NTIS  PB94-146289 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used to determine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies. (Copyright (c) 1993 American Society for Microbiology.)