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RECORD NUMBER: 50 OF 69

OLS Field Name OLS Field Data
Main Title Non-Regulated Study: Immune Effects of Oral Exposure of Human Volunteers to Octamethylcyclotetrasiloxane (D4), with Cover Letter dated 12/04/1998.
CORP Author Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1998
Stock Number OTS0573865
Additional Subjects Toxicology ; Health effects ; Octamethylcyclotetrasiloxane ; Biochemistry ; Mammals ; Humans ; Oral ; Diet ; CAS No 556-67-2
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NTIS  OTS0573865 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/09/2010
Collation 102p
Abstract
Humans are exposed to many commercial and consumer products that contain siloxanes. We investigated the immunological effects of a two-week oral exposure to octamethyicyclotetrasiloxane (Da). Normal volunteers ingested either 12 mg of 04 in com oil or corn oil alone in a double-blind, placebo-controlled, crossover study design. Immunological assays were chosen to screen for an immunotoxic or adjuvant effect. Assays for immunatoxicity included enumeration of peripheral lymphocyte subsets and functional assays using peripheral blood mononuclear cells. Because in humans there is no direct test for adjuvant effect of siloxane exposure, we analyzed pro-inflammatory cytokines and acute phase reactants in peripheral blood as surrogate markers for adjuvancy. Blood was obtained prior to exposure, and after 7 and 14 days of exposure. In these controlled human exposures, no immunotoxic or pro-inflammatonfladjuvant effect of D4 ingestion was found.