Record Display for the EPA National Library Catalog
RECORD NUMBER: 23 OF 69
|OLS Field Name||OLS Field Data|
|Main Title||Evaluation of Octamethylcyclotetrasiloxane as a Potential Inhibitor of Human Cytochrome P450 Enzymes: Amendment to Report No. 1998-I0000-44753, with Cover Letter dated 02/25/1999.|
|CORP Author||Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Octamethylcyclotetrasiloxane ; Pharmaco kinetics ; Mammals ; Humans ; In vitro ; CAS No 541-02-6 ; CAS No 541-05-9 ; CAS No 556-67-2|
This study was designed to evaluate the ability of D4 to inhibit the major P450 enzymes in human liver microsomes (namely CYPiA2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4/5 and CYP4A9/11), with the aim of ascertaining the potential of D4 to inhibit the metabolism of drugs and other foreign chemicals. In addition to human liver microsomes, D4 was evaluated for its ability to inhibit CYP1A1/2 and CYP2B1/2 in liver microsomes from rats treated with 3-methylcholanthrene and phenobarbital, respectively.