Record Display for the EPA National Library Catalog


Main Title Extrapolation of Inhaled Particulate Toxicity Data from Experimental Animals to Humans.
Author Morgan, D. L. ; Steele, V. E. ; Hatch, G. E. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Inhalation Toxicology Div.
Publisher Feb 88
Year Published 1988
Stock Number AD-A201 994/1
Additional Subjects Alveoli ; Animals ; Cells(Biology) ; Cultures(Biology) ; Dosage ; Extrapolation ; Humans ; Laboratory animals ; Models ; Nucleotides ; Particulates ; Phagocytes ; Respiratory system ; Reticuloendothelial system ; Sampling ; Sensitivity ; Tissues(Biology) ; Toxic agents ; Toxicity ; Toxicology ; Value ; Inhalation ; Experimental data ; Risk assessment ; Mathematical models
Library Call Number Additional Info Location Last
NTIS  AD-A201 994/1 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 77p
Significant progress has been made over the past three years to develop methodology and assess various tissues and tissue sensitivity endpoints with the ultimate goal of validating a proposed extrapolation model. This model will allow the quantitative extrapolation of inhaled particulate toxicology data from experimental animals to man. Methodology was developed to accurately measure nucleotide levels in small tissue samples, to determine cellular toxicant levels, to isolate tissue or cells at various levels of the respiratory tract, and to culture animal and human cells for identical treatment conditions. The tissues assessed were nasal turbinate epithelial, olfactory epithelial, and alveolar macrophages. Nasal and pulmonary lavage fluids were also studied. These comprehensive, comparative animal to human extrapolation studies were unique in that, for the first time, tissue response was measured as a function of actual cellular dose, and common endpoints were used for the same target cell types in different species. The described cell sensitivity model could then be used to provide quantitative animal to human extrapolation values for inhaled particulates, which will be extremely valuable for human risk assessment. Keywords: Models; Risk assessment; Toxicity. (KT)