Record Display for the EPA National Library Catalog


Main Title Nickel Absorption and Kinetics in Human Volunteers.
Author Sunderman, F. W. ; Hopfer, S. M. ; Sweeney, K. R. ; Marcus, A. H. ; Most, B. M. ;
CORP Author Connecticut Univ. Health Center, Farmington. School of Medicine. ;NSI Technology Services Corp., Research Triangle Park, NC.;Environmental Protection Agency, Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA-R813456; EPA/600/J-89/270;
Stock Number PB90-198094
Additional Subjects Nickel ; Toxicology ; Humans ; Kidney ; Feces ; Urine ; Blood serum ; Graphs(Charts) ; Reprints ; Pharmacokinetics ; Environmental exposure pathways ; Atomic absorption spectrophotometry
Library Call Number Additional Info Location Last
NTIS  PB90-198094 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Mathematical modeling was performed of the kinetics of nickel absorption, distribution and elimination in healthy human volunteers, who ingested NiSO4 in drinking water or added food. Nickel was analyzed by electrothermal atomic absorption spectrophotometry in serum, urine, and feces collected during 2 days before and 4 days after a specified NiSO4 dose (12 ug Ni/kg, N=4; 18 ug Ni/kg, N=4; or 50 ug Ni/kg, N=1). The study confirms that dietary constituents profoundly reduce the bioavailability of Ni2+ for alimentary absorption; approximately one-quarter of nickel ingested in drinking water after an over-night fast is absorbed from the human intestine and excreted in urine, compared to only one percent of nickel ingested in food. The compartmental model and kinetic parameters provided by the study will reduce the uncertainty of toxicological risk assessments of human exposures to nickel in drinking water and food. (Copyright (c) 1989 Society of Experimental Biology and Medicine.)