Record Display for the EPA National Library Catalog


Main Title Health assessment document for nickel and nickel compounds : final report.
Author Bayard, S. ; Beliles, R. ; Brooks, G. ; Chu, M. ; Crocetti, A.
CORP Author United States. Environmental Protection Agency.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Year Published 1986
Report Number EPA/600/8-83/012 FF
Stock Number PB86-232212
OCLC Number 15027127
Subjects Nickel--Toxicology ; Nickel compounds--Toxicology
Additional Subjects Nickel--Toxicology ; Public health ; Environmental surveys ; Distribution ; Toxicology ; Assessments ; Risk ; Physical properties ; Chemical properties ; Metals ; Health risks ; Heavy metals ; Cancer
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  RA1231.N44H42 1986 Region 1 Library/Boston,MA 04/29/2016
EJED  EPA 600/8-83-012FF OCSPP Chemical Library/Washington,DC 01/01/1988
EKBD  EPA/600/8-83/012FF Research Triangle Park Library/RTP, NC 08/02/1996
ELBD ARCHIVE EPA 600-8-83-012FF Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-8-83-012FF AWBERC Library/Cincinnati,OH 01/28/1989
ERAD  EPA 600/8-83/012 FF Region 9 Library/San Francisco,CA 02/26/2013
ESAD  EPA 600-8-83-012FF Region 10 Library/Seattle,WA 07/29/2005
NTIS  PB86-232212 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) : illustrations ; 28 cm
The predominant atmospheric forms of nickel are as sulfate, oxides, and complex oxides. Nickel also occurs in ambient and drinking waters and soils. Routes of intake for man are inhalation, ingestion, and percutaneous absorption. Pulmonary absorption varies according to chemical and physical form of the compound. While gastrointestinal intake ranges from 300 to 500 microgram daily, absorption is only one to ten percent of intake. Percutaneous absorption, usually through contact with nickel alloys in the household, is related to hypersensitivity and skin disorders. Inhaled nickel compounds lead to highest levels in lung, brain, kidney, and liver. Nickel exposure produces chronic dermatological, respiratory, endocrine and cardiovascular effects. Reproductive and developmental effects have been found in animals but not humans. Various nickel compounds have been tested for mutagenicity, demonstrating the ability of nickel compounds to produce genotoxic effects; the translation of these effects into actual mutations is still not clearly understood. There is evidence both in humans and animals for the carcinogenicity of nickel in some forms. Lifetime cancer risks for continuous inhalation exposure at 1 microgram nickel/cu. m. have been estimated for nickel refinery dust and nickel subsulfide. There is growing evidence that nickel may be an essential element for humans.
Distributed to depository libraries in microfiche. "September 1986." Includes bibliographical references. "EPA/600/8-83/012FF."