Record Display for the EPA National Library Catalog


Main Title Electrophysiological Assessment of Sensory and Cognitive Function in Children Exposed to Lead: A Review.
Author Otto, D. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/D-87/296;
Stock Number PB88-103148
Additional Subjects Lead(Metal) ; Absorption ; Evoked potential ; Electrophysiology ; Neural transmission ; Cognition ; Senses ; Children ;
Library Call Number Additional Info Location Last
NTIS  PB88-103148 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 25p
Studies of the effects of lead absorption on sensory evoked and slow brain potentials in children are reviewed. Studies of slow wave voltage in children during sensory conditioning indicated a linear relationship to blood lead level in two studies; an effect that could not be replicated in an independent sample of children. Results of a fourth study indicated that slow voltage measures were more sensitive to lead during active rather than passive conditioning. Conflicting evidence of lead effects on pattern-reversal visual evoked potentials in children was found in three studies. Evidence of increased latencies of brainstorm auditory evoked potentials at blood lead levels above 25/dl were reported in two studies. Sensory evoked potentials hold considerable promise as noninvasive, clinically valid, culture free measures of the effects of lead exposure on sensory nerve conduction, but further study is needed in humans and animals to clarify inconsistencies in the existing literature.