||Cytogenetic Distinction between the TK+ and TK- Chromosomes in the L5178Y TK+/- 3.7.2C Mouse-Lymphoma Cell Line.
Hozier, J. ;
Sawyer, J. ;
Clive, D. ;
Moore, M. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Florida Inst. of Tech., Melbourne.;Burroughs Wellcome Co., Research Triangle Park, NC.
Cell lines ;
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The authors have analyzed the banded metaphase karyotypes of the L5178Y TK+/-3.72C mouse-lymphoma cell line as well as a class of slow growing (o) TK-/-mutants which show chromosome 11 rearrangements. The authors have discovered a centromeric heteromorphism in the chromosomes 11 (the known location of the thymidine kinase gene in the mouse) which, together with the types of chromosome rearrangements thus far catalogued for TK+/- TK-/- mutagenesis, allows us to propose a cytogenetic distinction between the TK-competent (TK+) and TK-deficient (TK-) chromosome.