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Main Title Validation of chemical and biological techniques for evaluation of vapors in ambient air/mutagenicity testing of twelve (12) vapor-phase compounds /
Author Hughes, T. ; Sparacino, C. ; Frazier, S.
Other Authors
Author Title of a Work
Sparacino, Charles.
Frazier, Steven.
CORP Author Research Triangle Inst., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1984
Report Number EPA/600/1-84/005; EPA-68-02-3170
Stock Number PB84-164219
Subjects Air--Analysis ; Mutagenicity testing
Additional Subjects Mutagens ; Air pollution ; Chemical analysis ; Bioassay ; Laboratory animals ; Sampling ; Chloromethanes ; Formaldehyde ; Epichlorohydrin ; Toxicity ; Ethylene oxide ; Nitrobenzenes ; Hydrogen sulfide ; Butenes ; Propylene ; Acetylene ; Ames bioassay ; Toxic substances ; Tenax resins ; Methane/chloro ; Ethylene/trichloro ; Aroclors ; Ethane/dichloro ; Propane/nitro
Library Call Number Additional Info Location Last
NTIS  PB84-164219 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 204 pages ; 28 cm
The overall objective of this research was to further validate Ames mutagenicity preincubation system for detection of vapors in ambient air. Parametes for detection of vapors in the Ames/Salmonella mutagenicity assay were investigated and 12 vapor-phase compounds were tested for mutagenic potential in the above validated protocol with strains TA97, TA98 and TA100, both with and without Aroclor-induced hamster and rat liver S9. The 12 vapor-phase compounds tested were: methylene chloride, formaldehyde, trichloroethylene, ethylene dichloride, epichlorohydrin, nitropropane, nitrobenzene, hydrogen sulfide, butene, propylene, acetylene, and ethylene oxide. Ethylene oxide, epichlorohydrin, ethylene dichloride and methylene chloride were mutagenic.
Caption title. "March 1984." "EPA-600/1-84-005." Microfiche.