Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Summary of the Second EPA (Environmental Protection Agency) Workshop on Carcinogenesis Bioassay via the Dermal Route.
Author Argus, M. ; Baetcke, K. ; Turner, V. ; Cullen, L. ; Segal., S. A. ;
CORP Author Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher May 88
Year Published 1988
Report Number EPA-68-01-7266; EPA/560/6-89/003;
Stock Number PB90-146358
Additional Subjects Meetings ; Skin(Anatomy) ; Toxicology ; Laboratory animals ; Pathology ; Histology ; Bioassay ; Carcinogenicity tests ; Health planning guidelines ; Pharmacokinetics ; Maximum permissible dose ; Environmental exposure pathway ; Species specificity
Library Call Number Additional Info Location Last
NTIS  PB90-146358 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/15/1990
Collation 14p
The purpose of the workshop was to gather information and expert opinions to aid EPA in drawing up guidelines for carrying out carcinogenesis bioassays via the dermal route. At the first workshop in April 1987, consensus was reached on many aspects of this problem. The following areas were pinpointed as requiring further consideration in a second workshop before the desired guidelines can be written: the selection of species and strain; the role of pharmacokinetics; and the establishing of the Maximum Tolerated Dose(MTD). This includes the unique situation where skin may be the target organ for the toxicity end-point to arrive at the MTD. At the April 1987 workshop it was decided that these end-points involving the skin should be determined on both gross and histological considerations, and that the second workshop should include both pathologists and toxicologists. These considerations thus provide the basis for the agenda and roster of participants for the second workshop.