Record Display for the EPA National Library Catalog


Main Title Increased Susceptibility to Pentobarbital Following Mouse Cytomegalovirus Infection: Relative Roles of Viral-Induced Interferon and Viral Infection of the Liver.
Author Catignani, J. C. ; Menache, M. G. ; Selgrade, M. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div. ;North Carolina Univ. at Chapel Hill. School of Public Health. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/D-90/039;
Stock Number PB90-221714
Additional Subjects Liver diseases ; Toxicology ; Pentobarbital ; Mice ; Antibodies ; Graphs(Charts) ; Enzyme inhibitors ; Reprints ; Cytomegalic inclusion disease ; Interferon ; Cytomegaloviruses ; Disease susceptibility ; Cytochrome P-450
Library Call Number Additional Info Location Last
NTIS  PB90-221714 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
The purpose of the study was to determine the relative roles of viral-induced interferon (IFN) and viral infection of the liver in mouse cytomegalovirus (MCMV)-induced depression of cytochrome P-450 (cyt P-450) levels and enhancement of pentobarbital-induced sleeping time (PEN-ST). This was done by establishing the temporal relationship among the IFN response, viral infection of the liver, suppression of cyt P-450 levels, and enhancement of PEN-ST, by determining the effect of anti-IFN antibody treatment on all of these responses, and by manipulating factors known to influence viral pathogenesis and host response to virus such as animal age, virulence of the virus, and dose of virus. (Copyright (c) 1989 VCH Publishers, Inc.)