Record Display for the EPA National Library CatalogRECORD NUMBER: 16 OF 31
|Main Title||Induced Cytochrome P4501A in Winter Flounder, 'Pleuronectes americanus', from Offshore and Coastal Sites.|
|Author||Monosson, E. ; Stegeman, J. J. ;|
|CORP Author||AScI Corp., Narragansett, RI. ;Woods Hole Oceanographic Institution, MA. Dept. of Biology.;Environmental Research Lab., Narragansett, RI.|
|Report Number||EPA-R813155; EPA/600/J-94/504 ; ERLN-X190|
|Additional Subjects||Water pollution effects(Animals) ; Fish diseases ; Liver diseases ; Biological effects ; Marine animals ; Coastal regions ; Sediments ; Cape Cod ; Georges Bank ; Proteins ; Reprints ; CYP1A(Cytochrome P4501A) ; Winter flounders ; Atlantic Coast(United States) ; Pleuronectes americanus ; Aroclor 1254 ; Biphenyl/tetrachloro ; Ah receptor proteins|
In this study, we measured the content and activity of CYP1A in liver of winter flounder, Pleuronectes americanus, populations over a large geographic region ranging from New York , U.S.A., to New Brunswick, Canada, and investigated the relationship between content and activity of CYP1A and the concentration of PCBs in livers of flounder from sites along the New York and New England coast and Georges Bank. This comparison was the outgrowth of our search for flounder that would show at most slight indication of exposure to Ah receptor agonists or other contaminants. Locations of such 'reference' populations would be useful in helping to establish the etiology of hepatic neoplastic and other diseases of flounder living in the vicinity of contaminated sediments. Flounders in some locales bear neoplastic and other histological diseases that are thought to derive from environmental contamination.