Record Display for the EPA National Library Catalog


Main Title Use of leucocyte metabolism as a health effects indicator /
Author Lunan, Kenneth D.
CORP Author Stanford Research Inst., Menlo Park, Calif.;National Environmental Research Center, Research Triangle Park, N.C. Human Studies Lab.
Publisher Distributed by NTIS National Technical Information Service, U.S. Dept. of Commerce,
Year Published 1974
Report Number EPA 650-1-74-013; SRI-LSU-2430; EPA-68-02-0713; EPA-ROAP-21AYB-66; PB240174
Stock Number PB-240 174
OCLC Number 02889193
Subjects Leukocytes--metabolism ; Metals--toxicity
Additional Subjects Metals ; Leukocytes ; Toxicology ; Cadmium ; Lead(Metal) ; Platinum ; Permissible dosage ; Blood cells ; Biochemistry ; Physiology ; Anemias ; Rabbits ; In vitro analysis ; Experimental data ; Trace metals ; Indicators
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA 650-1-74-013 OCSPP Chemical Library/Washington,DC 07/12/2005
ELBD ARCHIVE EPA 650-1-74-013 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD RPS EPA 650-1-74-013 repository copy AWBERC Library/Cincinnati,OH 08/31/2020
NTIS  PB-240 174 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation ix, 93 pages : illustrations.
The objective of the study was to evaluate the use of leucocytes as a responsive bioindicator of lead, cadmium, and platinum intoxication in rabbits. Adult rabbits were injected intraperitoneally with cadmium chloride, lead acetate, and saline daily for one or three weeks. Toxicity studies established the maximum permissible dosages for the metal treatments. Leucocytes were isolated by density gradient centrifugation and examined for their ability to synthesize deoxyribonucleic acid, ribonucleic acid, protein, and phospholipid and to catabolize protein and phospholipid.
EPA 650/1 74-013.