Record Display for the EPA National Library Catalog


Main Title Sister Chromatid Exchange Analysis in Lung and Peripheral Blood Lymphocytes of Mice Exposed to Methyl Isocyanate by Inhalation (Journal Version).
Author Kligerman, A. D. ; Campbell, J. A. ; Erexson, G. L. ; Allen, J. W. ; Shelby, M. D. ;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA-68-02-4031; EPA/600/J-87/406;
Stock Number PB89-105522
Additional Subjects Toxic substances ; Isocyanates ; Cytogenetics ; Toxicity ; Sister chromatid exchange ; Inhalation ; Laboratory animals ; Nitrogen organic compounds ; Lung ; Lymphocytes ; Mitosis ; Mononuclear leukocytes ; Reprints ; Methyl isocyanate ; Isocyanato methane
Library Call Number Additional Info Location Last
NTIS  PB89-105522 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Mice were exposed to 1, 3, or 6 ppm methyl isocyanate (MIC) for 6 h/day for 4 consecutive days. Lung cells and peripheral blood lymphocytes (PBLs) were removed and cultured for analysis of sister chromatid exchange (SCE) and cell cycle kinetics. MIC caused a small but significant increase in SCE frequency of cultured lung cells from mice exposed to 1, 3, or 6 ppm MIC. MIC did not significantly increase SCE levels in PBLs of mice exposed to concentrations as high as 6 ppm. In cultured PBLs, MIC had a stimulatory effect on cell cycling rates as measured by the replicative index, and it caused a significant reduction in mononuclear leucocyte counts and the mitotic indices. (Copyright (c) 1987 Alan R. Liss, Inc.)