Record Display for the EPA National Library Catalog


Main Title Carcinogenic Effects of Benzene: An Update.
Author Bayliss, D. L. ; Chen, C. ; Jarabek, A. ; Sonawane, B. ; Valcovic, L. ;
CORP Author Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
Publisher May 98
Year Published 1998
Report Number EPA/600/P-97/001F ;NCEA-W-0268;
Stock Number PB99-101420
Additional Subjects Benzene ; Health effects ; Risk assessment ; Toxicity ; Health hazards ; Dose-response relationships ; Environmental exposure pathway ; Occupational exposure ; Children ; Pathogenesis ; Metabolism ; Amemia ; Malignant neoplasms ; Mortality ; Leukemia ; Epidemiology ; Carcinogens ; Inhalation ; Linear models ;
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB99-101420 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 78p
The major issue addressed in this document involves the nature and magnitude of the inhalation risk of cancer to humans exposed to low levels of benzene. Occupational studies continue to provide the bulk of evidence of benzene's carcinogenicity. This document reconfirms that benzene is a 'known' human carcinogen by all routes of exposure. This finding is supported by evidence from human epidemiologic studies, animal data, and an improvement in understanding of mechanisms(s) of action. Human epidemiologic studies of highly expose occupational cohorts have demonstrated that inhalation exposure to benzene can cause acute nonlymphocytic leukemia and other blood disorders, that is preleukemia and aplastic anemia. Additionally, changes in blood and bone marrow consistent with hematotoxicity are recognized in humans experimental animals. Currently, there is insufficient evidence to deviate from using an assumption of a linear dose-response curve for benzene, hence, the Agency's past approach of using a model with low-dose linearity is still recommended.