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Main Title Chronic toxicity of lead and cadmium : I. changes in the central nervous system of the parental generation of rats after chronic intoxication with lead and cadmium /
Other Authors
Author Title of a Work
Herman, Zbigniew S.
Publisher Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1980
Report Number EPA-600/1-80-012
Stock Number PB81-110850
OCLC Number 07562712
Subjects Cadmium--Toxicology ; Lead--Toxicology ; Cadmium--Health aspects ; Lead--Health aspects ; Cadmium Poisoning ; Lead Poisoning
Additional Subjects Toxicology ; Lead(Metal) ; Cadmium ; Bioassay ; Rats ; Exposure ; Central nervous system ; Dosage ; Laboratory animals ; Experimental data ; Blood chemical analysis ; Liver ; Kidney ; Concentration(Composition) ; Trace elements ; Toxic substances ; Urinalysis ; Hyperkinesis ; Biogenic amines
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-80-012 Headquarters Library/Washington,DC 04/23/2014
EKBD  EPA-600/1-80-012 Research Triangle Park Library/RTP, NC 06/30/2000
ELBD ARCHIVE EPA 600-1-80-012 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-1-80-012 AWBERC Library/Cincinnati,OH 11/14/2003
NTIS  PB81-110850 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation iii, 16 p. ; 28 cm.
This paper examines the effects of chronic exposure to trace amounts of lead and cadmium on the central nervous system of male Westar rats. Treatments consisted of two levels of lead (5 or 50 ppm), two levels of cadmium (0.1 or 5 ppm), and two combined dosages (5 ppm lead and 0.1 ppm cadmium, or 50 ppm lead and 5 ppm cadmium). Treatments were administered in buffered drinking water. The lower dosages generally produced hyperactivity, while higher dosages produced hypoactivity. Effects of lead and cadmium on biogenic amines varied with dose and area of the brain. Biochemical analysis of blood and urine showed no changes in the hematocrit or hemoglobin, but the activity of Delta-ALA dehydratase and serum phosphatase were differentially affected. Concentrations of lead and cadmium in the liver and kidney increased, and positive interaction effects were noted. The results suggest that the level of biogenic amines in discrete brain areas is a very sensitive indicator of central nervous system toxicity to lead and/or cadmium.
"EPA-600/1-80-012". "Performing Organization: Departments of Pharmacology, Biochemistry, Cytology and Histology, Central Animal Farm of Silesian Medical Academy in Katowice, Poland"--Technical Report Data. "January 1980." "Slaska Akademia Medyczna, Katowice, Poland"--Cover. Includes bibliographical references (p. 14-16).